Document Details

Document Type : Article In Journal 
Document Title :
Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis
Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis
 
Document Language : English 
Abstract : Cell death with morphological and molecular features of apoptosis has been detected in osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the pathogenesis of OA. Identification of biomarkers of chondrocyte apoptosis may facilitate the development of novel therapies that may eliminate the cause or, at least, slow down the degenerative processes in OA. The aim of this review was to explore the molecular markers and signals that induce chondrocyte apoptosis in OA. A literature search was conducted in PubMed, Scopus, Web of Science and Google Scholar using the keywords chondrocyte death, apoptosis, osteoarthritis, autophagy and biomarker. Several molecules considered to be markers of chondrocyte apoptosis will be discussed in this brief review. Molecular markers and signalling pathways associated with chondroycte apoptosis may turn out to be therapeutic targets in OA and approaches aimed at neutralizing apoptosis-inducing molecules may at least delay the progression of cartilage degeneration in OA. 
ISSN : 1422-0067 
Journal Name : Int J Mol Sci 
Volume : 16 
Issue Number : 9 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Tuesday, April 26, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Giuseppe MusumeciMusumeci, Giuseppe Researcher g.musumeci@unict.it
Paola CastrogiovanniCastrogiovanni, Paola Researcher pacastro@unict.it
Francesca Maria TrovatoTrovato, Francesca MariaResearcher trovatofrancesca@gmail.com
Mohammad K. Al-WasiyahAl-Wasiyah, Mohammad K.Researcher alwasiyah@doctor.com
Mohammed H. AlqahtaniAlqahtani, Mohammed H.Researcher mhalqahtani@kau.edu.sa
Ali MobasheriMobasheri, Ali Researcher a.mobasheri@surrey.ac.uk

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