Document Details

Document Type : Article In Journal 
Document Title :
Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming
Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming
 
Document Language : English 
Abstract : Ionizing radiation has a variety of acute and long-lasting adverse effects on the immune system. Whereas measureable effects of radiation on immune cell cytotoxicity and population change have been well studied in human and animal models, little is known about the functional alterations of the surviving immune cells after ionizing radiation. The objective of this study was to delineate the effects of radiation on T cell function by studying the alterations of T cell receptor activation and metabolic changes in activated T cells isolated from previously irradiated animals. Using a global metabolomics profiling approach, for the first time we demonstrate that ionizing radiation impairs metabolic reprogramming of T cell activation, which leads to substantial decreases in the efficiency of key metabolic processes required for activation, such as glucose uptake, glycolysis, and energy metabolism. In-depth understanding of how radiation impacts T cell function highlighting modulation of metabolism during activation is not only a novel approach to investigate the pivotal processes in the shift of T cell homeostasis after radiation, it also may lead to new targets for therapeutic manipulation in the combination of radiotherapy and immune therapy. Given that appreciable effects were observed with as low as 10 cGy, our results also have implications for low dose environmental exposures. 
ISSN : 0 
Journal Name : International journal of biological sciences 
Volume : 11 
Issue Number : 7 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Sunday, April 24, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Heng-Hong LiLi, Heng-Hong Investigator hl234@georgetown.edu
Yi-wen WangWang, Yi-wen Researcher  
Renxiang ChenChen, Renxiang Researcher  
Bin ZhouZhou, Bin Researcher  
Jonathan D. AshwellAshwell, Jonathan D.Researcher  
Albert J. Fornace Jr.Fornace Jr., Albert J.Researcher  

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