Document Details

Document Type : Article In Journal 
Document Title :
Next Generation Sequencing of Acute Myeloid Leukemia: Influencing Prognosis
Next Generation Sequencing of Acute Myeloid Leukemia: Influencing Prognosis
 
Document Language : English 
Abstract : Acute myeloid leukemia (AML) is a clonal disorder of the blood forming cells characterized by accumulation of immature blast cells in the bone marrow and peripheral blood. Being a heterogeneous disease, AML has been the subject of numerous studies that focus on unraveling the clinical, cellular and molecular variations with the aim to better understand and treat the disease. Cytogenetic-risk stratification of AML is well established and commonly used by clinicians in therapeutic management of cases with chromosomal abnormalities. Successive inclusion of novel molecular abnormalities has substantially modified the classification and understanding of AML in the past decade. With the advent of next generation sequencing (NGS) technologies the discovery of novel molecular abnormalities has accelerated. NGS has been successfully used in several studies and has provided an unprecedented overview of molecular aberrations as well as the underlying clonal evolution in AML. The extended spectrum of abnormalities discovered by NGS is currently under extensive validation for their prognostic and therapeutic values. In this review we highlight the recent advances in the understanding of AML in the NGS era. 
ISSN : 1471-2164 
Journal Name : BMC Genomics 
Volume : 16 
Issue Number : 1 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Wednesday, April 20, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Asad Muhammad IlyasIlyas, Asad MuhammadInvestigator  
Sultan AhmadAhmad, Sultan Researcher  
Muhammad FaheemFaheem, Muhammad Researcher  
Muhammad Imran NaseerNaseer, Muhammad ImranResearcher  
Taha A KumosaniKumosani, Taha AResearcher  
Muhammad Hussain Al-QahtaniAl-Qahtani, Muhammad HussainResearcher  
Mamdooh GariGari, Mamdooh Researcher  
Farid AhmedAhmed, Farid Researcher  

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