Document Details

Document Type : Article In Journal 
Document Title :
A possible link of gut microbiota alteration in type 2 diabetes and Alzheimer's disease pathogenicity: an update.
A possible link of gut microbiota alteration in type 2 diabetes and Alzheimer's disease pathogenicity: an update.
 
Document Language : English 
Abstract : Imbalances in gut microbiota are associated with metabolic disorder, which are a group of obesity-related metabolic abnormalities that increase an individual's risk of developing type 2 diabetes (T2D) and Alzheimer's disease (AD). Although a number of risk factors have been postulated that may trigger the development of AD, the root cause of this disease is still a matter of debate. This review further investigates the etiology of AD by accumulating the current role played by gut microbiota in human, and trying to establish an inter-link between T2D and AD pathogenesis. There is a growing body of evidence which suggests that obesity is associated with alteration in the normal gut flora, reduced bacterial diversity, metabolic pathways and altered representation of bacterial genes. Obesity and T2D are considered to be induced as a result of changes within the composition of gut microbiota. The evidence gathered so far clearly advocates the involvement of gut microbes in causing obesity, a state of chronic and low-grade inflammation. Hence, understanding the microbiota of the gut is significant in relation to inflammation, as it is a key contributor for diabetes which has a direct relation to the AD pathogenesis. Comparative analysis of gut microbiota may enable further novel insight into the complex biology of AD, which is very important in order to take preventive measure such as early diagnosis, identification of new therapeutic targets and development of novel drugs. 
ISSN : 1871-5273 
Journal Name : CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorder 
Volume : 13 
Issue Number : 3 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Thursday, April 14, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Mohammad Z AlamZ Alam, Mohammad Researcher  
Qamre AlamAlam, Qamre Researcher  
Mohammad A KamalA Kamal, Mohammad Researcher  
Adel M AbuzenadahM Abuzenadah, Adel Researcher  
Absarul HaqueHaque, Absarul Investigator  

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