Document Details

Document Type : Article In Journal 
Document Title :
LUD, a new protein domain associated with lactate utilization
LUD, a new protein domain associated with lactate utilization
 
Document Language : English 
Abstract : BACKGROUND: A novel highly conserved protein domain, DUF162 [Pfam: PF02589], can be mapped to two proteins: LutB and LutC. Both proteins are encoded by a highly conserved LutABC operon, which has been implicated in lactate utilization in bacteria. Based on our analysis of its sequence, structure, and recent experimental evidence reported by other groups, we hereby redefine DUF162 as the LUD domain family. RESULTS: JCSG solved the first crystal structure [PDB:2G40] from the LUD domain family: LutC protein, encoded by ORF DR_1909, of Deinococcus radiodurans. LutC shares features with domains in the functionally diverse ISOCOT superfamily. We have observed that the LUD domain has an increased abundance in the human gut microbiome. CONCLUSIONS: We propose a model for the substrate and cofactor binding and regulation in LUD domain. The significance of LUD-containing proteins in the human gut microbiome, and the implication of lactate metabolism in the radiation-resistance of Deinococcus radiodurans are discussed. 
ISSN : 1471-2105 
Journal Name : BMC bioinformatics 
Volume : 14 
Issue Number : 1 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Tuesday, April 5, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
William C HwangHwang, William C Investigator  
Constantina BakolitsaBakolitsa, Constantina Researcher  
Marco PuntaPunta, Marco Researcher  
Penelope C CoggillCoggill, Penelope C Researcher  
Alex BatemanBateman, Alex Researcher  
Herbert L AxelrodAxelrod, Herbert L Researcher  
Neil D RawlingsRawlings, Neil D Researcher  
Mayya SedovaSedova, Mayya Researcher  
Scott N PetersonPeterson, Scott N Researcher  
Ruth Y EberhardtEberhardt, Ruth Y Researcher  
L AravindAravind, L Researcher  
Jaime PascualPascual, Jaime Researcher  
Adam GodzikGodzik, Adam Investigator  

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