Document Details

Document Type : Article In Journal 
Document Title :
An association of virus infection with type 2 diabetes and Alzheimer’s disease
An association of virus infection with type 2 diabetes and Alzheimer’s disease
 
Document Language : English 
Abstract : Diabetes mellitus type 2 is a metabolic disorder characterized by high blood glucose due to insulin deficiency or resistance. Alzheimer's disease (AD) is a complex neurodegenerative disease leading to irreversible loss of neurons, intellectual abilities, memory and reasoning. The worldwide prevalence of diabetes and AD in elderly population is a major public health concern. Interestingly, both health issues are unraveling the puzzling links. The clinico-pathological relationship between diabetes and AD has been reported at genomic and proteomic levels. The association of virus infection in type 2 diabetes mellitus and AD has been reported in few recent studies, some have shown direct evidence of virus infection in diabetes and AD while other have shown that diabetes increases the risk of developing AD. This review aims to summarize the association of few common viruses like Hepatitis C Virus and Herpes Simplex Virus-1 which affects both these two age-related devastating diseases. We also discuss the pathological links of Influenza virus, Cytomegalovirus, West Nile virus, Enterovirus, Herpes Simplex Virus-2, Hepatitis viruses in diabetes and Influenza virus, Picornavirus and Borna disease virus in AD. Establishing such relationships and defining their common pathogenesis and patho-physiological mechanisms may lead to new concepts and paths for developing novel preventive strategies and pharmacological treatment options for diabetes and AD. This study may aid in future for the identification of a single or a panel of likely blood-based viral biomarkers for early diagnosis of diabetes and AD with high sensitivity and specificity. 
ISSN : 1871-5273 
Journal Name : CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorder 
Volume : 13 
Issue Number : 3 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Tuesday, April 5, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Sajjad KarimKarim, Sajjad Researcher  
Zeenat MirzaMirza, Zeenat Researcher  
Mohammad A KamalA Kamal, Mohammad Researcher  
Adel M AbuzenadahM Abuzenadah, Adel Researcher  
Esam I AzharI Azhar, Esam Researcher  
Mohammad H Al-QahtaniH Al-Qahtani, Mohammad Researcher  
Sayed S SohrabS Sohrab, Sayed Investigator  

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