Document Details

Document Type : Article In Journal 
Document Title :
Molecular characterization of FLT3 mutations in acute leukemia patients
Molecular characterization of FLT3 mutations in acute leukemia patients
 
Document Language : English 
Abstract : Fms-like tyrosine kinase 3 (FLT3) performs a vital role in the pathogenesis of hematopoietic malignancies. Therefore in recent times, the focus of several studies was on use of FLT3 as a prognostic marker. The present study investigated the molecular characterization and incidence of FLT3 mutations in acute leukemia patients in Pakistan. A total of 55 patients were studied, of which 25 were suffering from acute lymphoblastic leukemia (ALL) and 30 were suffering from acute myeloid leukemia (AML). The polymerase chain reaction demonstrated FLT3/ ITD mutations in 1 (4%) of 25 ALL patients, a male with the L2 subtype. In AML cases the rate was 4 (13.3%) of 30, three males and one female. The AML-M4 subtype was found in three and the AML M2 subtype in the other. In the AML cases, a statistically significant (p=0.009) relationship was found between WBC (109/L) and FLT3/ ITD positivity. However, no significant relationship was found with other clinical parameters (p>0.05). In acute myeloid leukemia (AML) FLT3/ITD+ mutation was more prevalent in elderly patients 31-40 age groups, 21-30 and 51-60 age groups respectively. In acute lymphoblastic leukemia (ALL) statistically no significant relationship was found between clinical features and FLT3/ITD positivity (p>0.05). However, in acute lymphoblastic leukemia (ALL) FLT3/ITD+ mutation was more commonly found in age groups of 21-30. 
ISSN : 1513-7368 
Journal Name : Asian Pacific Journal of Cancer Prevention 
Volume : 13 
Issue Number : 9 
Publishing Year : 1433 AH
2012 AD 
Article Type : Article 
Added Date : Thursday, March 10, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Mariam IshfaqIshfaq, Mariam Investigator  
Arif MalikMalik, Arif Researcher  
Mariam FaizFaiz, Mariam Researcher  
Ishfaq Ahmad SheikhSheikh, Ishfaq Ahmad Researcher  
Muhammad AsifAsif, Muhammad Researcher  
Muhammad Nasrullah KhanKhan, Muhammad Nasrullah Researcher  
Muhammad Saeed QureshiQureshi, Muhammad Saeed Researcher  
Sara ZahidZahid, Sara Researcher  
Abdul MananManan, Abdul Researcher  
Mahwish AroojArooj, Mahwish Researcher  

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