Document Details

Document Type : Article In Journal 
Document Title :
Interleukin‐33 exacerbates acute colitis via interleukin‐4 in mice
Interleukin‐33 exacerbates acute colitis via interleukin‐4 in mice
 
Document Language : English 
Abstract : Interleukin-33 (IL-33) and its receptor ST2 are over-expressed in clinical colitis tissue. However, the significance of these observations is at present unknown. Significantly, we demonstrate here that IL33 and ST2 are the primary early genes induced in the inflamed colon of BALB/c mice following dextran sulphate sodium (DSS)-induced experimental ulcerative colitis. Accordingly diarrhoea and DSS-induced colon inflammation were impaired in ST2(-/-) BALB/c mice and exacerbated in wild-type mice by treatment with exogenous recombinant IL-33, associated respectively with reduced and enhanced expression of chemokines (CXCL9 and CXCL10), and inflammatory (IL-4, IL-13, IL-1, IL-6, IL-17) and angiogenic (vascular endothelial growth factor) cytokines in vivo. The exacerbation effect of treatment with recombinant IL-33 on DSS-induced acute colitis was abolished in IL-4(-/-) BALB/c mice. Hence, IL-33 signalling via ST2, by inducing an IL-4-dependent immune response, may be a major pathogenic factor in the exacerbation of ulcerative colitis. 
ISSN : 1365-2567 
Journal Name : Immunology 
Volume : 140 
Issue Number : 1 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Thursday, March 10, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Peter N PushparajPushparaj, Peter N Investigator  
Dong LiLi, Dong Researcher  
Mousa Komai‐KomaKomai‐Koma, Mousa Researcher  
Rodrigo GuabirabaGuabiraba, Rodrigo Researcher  
James AlexanderAlexander, James Researcher  
Charles McSharryMcSharry, Charles Researcher  
Damo XuXu, Damo Researcher  

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