Document Details

Document Type : Article In Journal 
Document Title :
Alzheimer's disease and type 2 diabetes: exploring the association to obesity and tyrosine hydroxylase
Alzheimer's disease and type 2 diabetes: exploring the association to obesity and tyrosine hydroxylase
 
Document Language : English 
Abstract : Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two debilitating health disorders afflicting millions worldwide. Recent research has revealed similarities between AD and T2DM. Both these protein conformational disorders are associated with obesity, insulin resistance, inflammation and endoplasmic reticulum stress, en-route initiation and/or stage aggravation. In this mini review we have tried to summarize studies describing obesity, insulin resistance and glucocorticoid imbalance as common patho-mechanisms in T2DM and AD. A reduction in tyrosine hydroxylase (TH) in the brain has been found to occur in Parkinson's disease (PD). AD, T2DM and PD share common risk factors like depression. Thus, whether TH is involved in the 'state of cognitive depression' that is the hallmark of AD and often accompanies PD and T2DM is also explored. 
ISSN : 1871-5273 
Journal Name : CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorder 
Volume : 11 
Issue Number : 4 
Publishing Year : 1433 AH
2012 AD 
Article Type : Article 
Added Date : Wednesday, March 9, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Medha PriyadarshiniPriyadarshini, Medha Investigator medha.priyadarshini@gmail.com
Mohammad A KamalA Kamal, Mohammad Researcher  
Nigel H GreigH Greig, Nigel Researcher  
Marcella RealefRealef, Marcella Researcher  
Adel M AbuzenadahAbuzenadah, Adel MResearcher  
Adeel GA ChaudharyChaudhary, Adeel GAResearcher  
Ghazi A DamanhouriDamanhouri, Ghazi AResearcher  

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