Document Details

Document Type : Article In Journal 
Document Title :
A molecular motor, KIF13A, controls anxiety by transporting the serotonin type 1A receptor
A molecular motor, KIF13A, controls anxiety by transporting the serotonin type 1A receptor
 
Document Language : English 
Abstract : Molecular motors are fundamental to neuronal morphogenesis and function. However, the extent to which molecular motors are involved in higher brain functions remains largely unknown. In this study, we show that mice deficient in the kinesin family motor protein KIF13A (Kif13a(-/-) mice) exhibit elevated anxiety-related behavioral phenotypes, probably because of a reduction in 5HT(1A) receptor (5HT(1A)R) transport. The cell-surface expression level of the 5HT(1A)R was reduced in KIF13A-knockdown neuroblastoma cells and Kif13a(-/-) hippocampal neurons. Biochemical analysis showed that the forkhead-associated (FHA) domain of KIF13A and an intracellular loop of the 5HT(1A)R are the interface between the motor and cargo vesicles. A minimotor consisting of the motor and FHA domains is able to transport 5HT(1A)R-carrying organelles in in vitro reconstitution assays. Collectively, our results suggest a role for this molecular motor in anxiety control. 
ISSN : 2211-1247 
Journal Name : Cell reports 
Volume : 3 
Issue Number : 2 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Tuesday, March 8, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Ruyun ZhouZhou, Ruyun Investigator  
Shinsuke NiwaNiwa, Shinsuke Researcher  
Laurent GuillaudGuillaud, Laurent Researcher  
Ying TongTong, Ying Researcher  
Nobutaka HirokawaHirokawa, Nobutaka Researcher  

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