Document Details

Document Type : Article In Journal 
Document Title :
New Delhi metallo-β-lactamase (NDM-1): an update
New Delhi metallo-β-lactamase (NDM-1): an update
 
Document Language : English 
Abstract : New Delhi metallo-β-lactamase (NDM-1) is a novel broad spectrum carbapenemase with ability to inactivate all β-lactams except aztreonam. However, most of the NDM-1-producers also produce aztreonam hydrolysing-β-lactamases thereby making these pathogens absolutely resistant to all β-lactams. The bla(NDM-1) gene encodes a 27.5 kDa protein of 269 amino acids. It shares very little identity with other metallo-β-lactamases. Maximum identity has been observed to VIM-1/VIM-2 (32.4%). This mini-review is an update of the scientific literature for the said enzyme. Following the recommendation of David livermore, we further propose to combine "aztreonam" and "inhibitor of the most frequently encountered aztreonam hydrolysing-β-lactamases in a given setting" as a possible strategy against NDM-1-producers. The inhibitor should be 'versatile' as well, i.e. it should have the ability to inhibit most of the variants of aztreonam hydrolysing-β-lactamases prevalent in the concerned setting. We strongly recommend surveillance studies using aztreonam/NXL-104-combination against NDM-1-producing pathogens in different geographical regions across the globe. 
ISSN : 1120-009X 
Journal Name : Journal of Chemotherapy 
Volume : 23 
Issue Number : 5 
Publishing Year : 1432 AH
2011 AD 
Article Type : Article 
Added Date : Tuesday, March 8, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
S ShakilShakil, S InvestigatorDoctorate 
EI AzharAzhar, EI Researcher  
S TabrezTabrez, S Researcher  
MA KamalKamal, MA Researcher  
NR JabirJabir, NR Researcher  
AM AbuzenadahAbuzenadah, AM Researcher  
GA DamanhouriDamanhouri, GA Researcher  
Q AlamAlam, Q Researcher  

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