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Document Type |
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Article In Journal |
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Document Title |
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An Interleukin-1 Genotype Is Associated with Fatal Outcome of Meningococcal Disease An Interleukin-1 Genotype Is Associated with Fatal Outcome of Meningococcal Disease |
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Document Language |
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English |
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Abstract |
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To determine whether known variants of the interleukin-1 (IL-1) and tumor necrosis factor
(TNF) gene families are associated with severe manifestations of meningococcal disease, 276
white patients 4–70 years of age (median, 17 years) were genotyped. All patients had microbiologically
proven Neisseria meningitidis infection; 39 died and 237 survived. A significant
association (P ! .001) was found between fatal outcome and genotype at IL1B (nucleotide
position 2511). Homozygous individuals, both for the common (1/1) and the rare (2/2) alleles,
had increased odds ratios (ORs) for death, compared with heterozygous individuals (1/2):
ORs (95% confidence intervals [CIs]) were 3.39 (1.39–8.29) and 7.35 (2.51–21.45), respectively.
The mortality rates according to genotype at IL1B (2511) were 18.0% (1/1), 6.1% (1/2), and
32.3% (2/2), compared with 14.2% overall. The composite genotype, consisting of heterozygosity
of IL1B (2511) together with homozygosity of the common allele of the IL-1 receptor
antagonist gene (IL1RN) at +2018, was significantly associated with survival (Pp.018; OR,
7.78 [95% CI, 1.05–59.05]). There was no association between TNF genotype and fatal outcome.
These data suggest that IL-1 genotype influences the severity of meningococcal disease. |
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ISSN |
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1537-6613 |
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Journal Name |
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The Journal of Infectious Diseases |
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Volume |
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182 |
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Issue Number |
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5 |
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Publishing Year |
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1421 AH
2000 AD |
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Article Type |
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Article |
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Added Date |
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Tuesday, April 27, 2010 |
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Researchers
| Robert Read | Read, Robert | Investigator | Doctorate | r.c.read@sheffield.ac.uk |
| عديل شودري | Chaudhary, Adeel | Researcher | Doctorate | |
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