جامعة الملك عبدالعزيز

KING ABDULAZIZ UNIVERSITY

Center of Excellence In Genomic Medicine Research

Neurodegenerative Research Group (NDRG)

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     This program focuses on neurodegenerative disorders, a group of disorders characterized by loss of structure or function of neurons. They share many similarities on the subcellular level which offers hope for therapeutic advances that could ameliorate these diseases.

     Many of these diseases are caused by gene mutations in unrelated genes and many share the common feature of repeat of the CAG nucleotide triplet (dynamic mutations). The most common are Huntington's disease, spinocerebellar ataxia, Myotonic dystrophy and Fragile X syndrome. The genetic causes of most of these diseases have never been addressed in Saudi Arabia and the published articles are extremely limited with few studies at clinical level only.
 
    The research group is starting a project aiming to establish a diagnostic technique for the screening of FRAX disease among patients with mental retardation. The CEGMR will benefit from the new technology such as SNP Microarray and Next generation sequencing for exploration of the genetic basis of these diseases which could help in the diagnosis, prevention and development of therapeutic intervention.

Neurodegenerative Research Group

Dr. Hussein Al Gahtani
King Khaled National Guard Hospital
Prof. Mohammed M.S. Jan
Faculty of Medicine, King Abdulaziz University
Prof. Adeel Chaudhary
Faculty of Medical Technology and CEGMR, King Abdulaziz University
Prof. Ibtessam Ramzi Hussein
CEGMR, King Abdulaziz University
Dr. Doaa Ahmed Mahmoud Khalifa
Department of Psychiatry, Faculty of Medicine, King Abdulaziz University
Dr. Faten N. AL-zaben
Department of Psychiatry, Faculty of Medicine, King Abdulaziz University
Dr. Muhammad Imran Naseer
CEGMR, King Abdulaziz University


International Collaborator:

Prof. Stephen Scherer
Director of the McLaughlin Centre and Centre for Applied Genomics
Hospital for Sick Children and University of Toronto,
Canada
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Last Update 2/23/2016 1:31:47 PM