تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy
Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy
 
لغة الوثيقة : الانجليزية 
المستخلص : Systematic administration of interferon-alpha (INF-alpha) is considered as the backbone of HCV therapy since 1991. Interferon (IFN) therapy can cause vasculitis, glomerulonephritis, cryoglobulinemia and certain other autoimmune diseases such as sialoadentitis, lichen planus and thyroiditis. Related to the factors of interferons, extensively studied gland is thyroid gland. A strong association was observed between thyroid disease and HCV patient when they were exposed to IFN therapy. Vitamin D, malondialdehyde (MDA), thyroid hormones and auto antibodies were biochemically assessed from the venous blood of seventy five HCV patients and fifty healthy controls. The results of all parameters were analyzed by independent sample t-test. The results of the study demonstrated a clear picture that the levels of vitamin D decreased as compared to control but increases in case of MDA. The levels of antibody titer represent that thyroglobulin-antibody (TGAb) thyroid peroxidase-antibody (TPOAb) as well as thyroid stimulating hormone receptor-antibody (TSHRAb) were raised in the patients suffering from HCV with thyroid dysfunction as compared to control. Similarly, the levels of thyroid hormones were also elevated in the HCV patients. Antibodies generated against thyroidal enzymes leads to impaired function of these enzymes thus causing decreased synthesis of thyroid hormones. As exogenous INF triggers the release of cytokines that mediate the recruitment of immune cells with increased production of inflammatory markers lead to production of lytic granules which have direct toxic action on thyroid cells and ultimately increased lipid peroxidation of thyrocytes. The results of the present study clearly demonstrated that the decreased levels of vitamin D in HCV patients receiving IFN therapy were responsible to induce autoimmunity against thyroid gland and adjutant therapy may be helpful to alleviate the possible thyroid disorders. 
ردمد : 2814-9047 
اسم الدورية : Bioinformation 
المجلد : 12 
العدد : 3 
سنة النشر : 1437 هـ
2016 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Thursday, July 20, 2017 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Mahwish AroojArooj, Mahwish باحثدكتوراه 
Arif MalikMalik, Arif باحثدكتوراه 
Abdul BasitBasit, Abdul باحثدكتوراه 
Mahmood Husain QaziQazi, Mahmood Husainباحثدكتوراه 
Muhammad AsifAsif, Muhammad باحثدكتوراه 
Mohammad Sarwar JamalJamal, Mohammad Sarwarباحثدكتوراه 
Maged Mostafa MahmoudMahmoud, Maged Mostafaباحثدكتوراه 
Hani ChoudhryChoudhry, Hani باحثدكتوراه 
Peter Natesan PushparajPushparaj, Peter Natesanباحثدكتوراه 
Mahmood RasoolRasool, Mahmood باحثدكتوراهmahmoodrasool@yahoo.com

الملفات

اسم الملفالنوعالوصف
 42146.pdf pdf 

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