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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Evaluation of matrix metalloproteinases, cytokines and their potential role in the development of ovarian cancer
Evaluation of matrix metalloproteinases, cytokines and their potential role in the development of ovarian cancer
 
لغة الوثيقة : الانجليزية 
المستخلص : Background Ovarian cancer is the 5th most common cause of deaths in the women among gynecological tumors. There are many growing evidences that stress and other behavioral factors may affect cancer progression and patient survival. The purpose of this study is to determine the key role of matrix metalloproteinases (MMPs), and cytokines in the aggregation and progression of ovarian cancer. Methodology Stress variables (MDA, AGEs, AOPPs, NO), profile of antioxidants (SOD, Catalase, Vitamin E & A, GSH, GRx, GPx) and inflammatory biomarkers (MMP-9, MMP-2, MMP-11, IL-1α and TNF-α) were biochemically assessed from venous blood of fifty ovarian cancer patients and twenty healthy control subjects. The results of all parameters were analyzed statistically by independent sample t-test. Results The results of the study demonstrated that the levels of stress variables like MDA (3.38±1.12nmol/ml), AGEs (2.72±0.22 ng/ml), AOPPs (128.48±27.23 ng/ml) and NO (58.71±8.67 ng/ml) were increased in the patients of ovarian cancer as compared to control individuals whereas the profile of antioxidants like SOD, Catalase, Vitamin E, Vitamin A, GSH and GRx were decreased in ovarian cancer patients (0.11±0.08 μg/ml, 2.41±1.01μmol/mol of protein, 0.22±0.04 μg/ml, 45.84±9.07μg/ml, 4.88±1.18μg/ml, 5.33±1.26 μmol/ml respectively). But the level of GPx antioxidant was increased in ovarian cancer patients (6.58±0.21μmol/ml). Moreover the levels of MMP-9 (64.87±5.35 ng/ml), MMP-2 (75.87±18.82 ng/ml) and MMP-11 (63.58±8.48 ng/ml) were elevated in the patients. Similarly, the levels of various cytokines TNF-α and IL-1α were also increased in the patients of ovarian cancer (32.17±3.52 pg/ml and 7.04±0.85 pg/ml respectively). Conclusion MMPs are commonly expressed in ovarian cancer which are potential extrapolative biomarkers and have a major role in metastasis. Due to oxidative stress, different cytokines are released by tumor associated macrophages (TAMs) that result in the cancer progression. Consequently, tissue inhibitors of matrix metalloproteinases (TIMPs) are the valuable therapeutic approaches to complement conservative anticancer strategies. 
ردمد : 1932-6203 
اسم الدورية : PloS one 
المجلد : 11 
العدد : 11 
سنة النشر : 1437 هـ
2016 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Tuesday, July 18, 2017 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Mahmood RasoolRasool, Mahmood باحثدكتوراه 
Arif MalikMalik, Arif باحثدكتوراه 
Muhammad Abdul Basit AshrafAshraf, Muhammad Abdul Basitباحثدكتوراه 
Gulshan ParveenParveen, Gulshan باحثدكتوراه 
Shazia IqbalIqbal, Shazia باحثدكتوراه 
Irfan AliAli, Irfan باحثدكتوراه 
Mahmood Husain QaziQazi, Mahmood Husainباحثدكتوراه 
Muhammad AsifAsif, Muhammad باحثدكتوراه 
Kashif KamranKamran, Kashif باحثدكتوراه 
Asim IqbalIqbal, Asim باحثدكتوراه 
Saima IramIram, Saima باحثدكتوراه 
Sami Ullah KhanKhan, Sami Ullahباحثدكتوراه 
Mohammad Zahid MustafaMustafa, Mohammad Zahidباحثدكتوراه 
Ahmad ZaheerZaheer, Ahmad باحثدكتوراه 
Rozeena ShaikhShaikh, Rozeena باحثدكتوراه 
Hani ChoudhryChoudhry, Hani باحثدكتوراه 
Mohammad Sarwar JamalJamal, Mohammad Sarwarباحثدكتوراه 

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