تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
dRHP-PseRA: detecting remote homology proteins using profile-based pseudo protein sequence and rank aggregation
dRHP-PseRA: detecting remote homology proteins using profile-based pseudo protein sequence and rank aggregation
 
لغة الوثيقة : الانجليزية 
المستخلص : Protein remote homology detection is an important task in computational proteomics. Some computational methods have been proposed, which detect remote homology proteins based on different features and algorithms. As noted in previous studies, their predictive results are complementary to each other. Therefore, it is intriguing to explore whether these methods can be combined into one package so as to further enhance the performance power and application convenience. In view of this, we introduced a protein representation called profile-based pseudo protein sequence to extract the evolutionary information from the relevant profiles. Based on the concept of pseudo proteins, a new predictor, called “dRHP-PseRA”, was developed by combining four stateof- the-art predictors (PSI-BLAST, HHblits, Hmmer, and Coma) via the rank aggregation approach. Cross-validation tests on a SCOP benchmark dataset have demonstrated that the new predictor has remarkably outperformed any of the existing methods for the same purpose on ROC50 scores. Accordingly, it is anticipated that dRHP-PseRA holds very high potential to become a useful high throughput tool for detecting remote homology proteins. For the convenience of most experimental scientists, a web-server for dRHP-PseRA has been established at http://bioinformatics.hitsz.edu.cn/ dRHP-PseRA/. 
ردمد : 2045-2322 
اسم الدورية : Scientific reports 
المجلد : 6 
العدد : 1 
سنة النشر : 1437 هـ
2016 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Monday, July 17, 2017 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Junjie ChenChen, Junjie باحثدكتوراه 
Ren LongLong, Ren باحثدكتوراه 
Xiao-long WangWang, Xiao-long باحثدكتوراه 
Bin LiuLiu, Bin باحثدكتوراه 
Kuo-Chen ChouChou, Kuo-Chen باحثدكتوراه 

الملفات

اسم الملفالنوعالوصف
 42006.pdf pdf 

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