تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Diacylglycerol-mediated Signaling of Neutrophils in Diabetics with or without Periodontal Disease
Diacylglycerol-mediated Signaling of Neutrophils in Diabetics with or without Periodontal Disease
 
لغة الوثيقة : الانجليزية 
المستخلص : Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. Diacylglycerols (DAG) are a group of second messenger molecules involved in the regulation of neutrophil functions. DAG mass can be modified in diabetic cells through direct activation of endogenous signaling pathways and receptor mediated events triggered by advanced glycation endproducts (AGE). OBJECTIVE: The aim of this study was to evaluate total DAG content, and DAG kinase (DAGK) activity in neutrophils of diabetic patients with periodontal disease. METHODS: Diabetic subjects with periodontitis (N=15) were compared to matched-healthy subjects (N=15) with no periodontal disease. Peripheral blood neutrophils were isolated and total lipid was extracted. DAG content was measured by its phosphorylation to radioactively labeled phosphatidic acid (PA). For DAGK activity, the cells were suspended in lysis buffer and the conversion of external DAG substrate into PA was measured by the uptake of radioactivity as above. RESULTS: Total DAG levels were significantly higher in diabetic neutrophils compared to healthy individuals (diabetes = 9, healthy = 9) (p 
ردمد : 0 
اسم الدورية : JDR 
المجلد : 3082 
العدد : 2 
سنة النشر : 2003 هـ
2003 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Tuesday, May 20, 2008 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
ممدوح كريمةKarima, Mamdouh باحث رئيسيدكتوراهmkarimah@kau.edu.sa

الملفات

اسم الملفالنوعالوصف
 Diacylglycerol-mediated Signaling of.pdf pdf 

تحميل الصفحة

الرجوع إلى صفحة الأبحاث