Document Details

Document Type : Article In Journal 
Document Title :
NEUROTOXICITY FROM FRESHWATER OSCIL LATORIA BREVIS (KUTZ.) IN PORT-SAID, EGYPT
السمية العصبية من مصدر طحلب المياه العذبة، الأسيلاتوريه، بورسعيد-مصر
 
Document Language : Arabic 
Abstract : Algal and water samples were taken from freshwater source of Port-Said drinking water treatment plant to explore the cyanobacterial toxicity during the period from December 1995 to December 1999. Selected sampling stations were chosen to represent different sites on Port-Said freshwater canal to cover a distance of 39 Km away from the water treatment plant. Compact cyanobacterial cells were extracted by 1:1 (v/v) distilled water using ultrasonic cell disrupter. Cyanobacterial cell extract was examined for toxicity by mouse bioassay. Cyanobacterial bloom in Port-Said were recorded during winter from November to February of each year. Toxic bloom in Port-said freshwater was detected in December 1995, February 1998, and December 1999. After the isolation and purification of the dominating cyanobacterial species, the pure isolates were tested for toxicity. The toxic organism, unexpectedly, proved to be Oscillatoria brevis (Kutz.). FjPLC was used to analyze the crude toxic extract against the known algal neurotoxins, saxitoxins, anatoxin-A, and domoic acid and none of these toxins were found in the tested crude toxic extract. The toxin was partially purified by Ultrafiltration and toxicity was detected till less than 500 Dalton filtrate. The isolated toxin was found to be a sodium channel blocker. The toxicity profile showed that the threshold was at 7.5 mg/ml where a plateau was at 20 mg/ml. No inhibition activity of the isolated toxins against AchE was detected. 
ISSN : 12343 
Journal Name : Journal of Egyptian society for Toxicity 
Volume : 23 
Issue Number : 1 
Publishing Year : 1421 AH
2000 AD 
Article Type : Article 
Added Date : Saturday, January 8, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
محمد نصر الدين محمد جمعةGomaa, Mohamed Nasr Eldin mohamedInvestigatorDoctoratemngomaa@gmail.com

Files

File NameTypeDescription
 28516.pdf pdf 

Back To Researches Page