Document Details

Document Type : Thesis 
Document Title :
Detection of Dysbiosis in Vaginal Microbiome of Saudis Preterm Births in King Abdulaziz University Hospital
التعرف على اختلال التوازن في ميكروبيوم المهبل للولادات المبكرة للسعوديات في مستشفى جامعة الملك عبد العزيز
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Background/Aims: The microbiome is thought to play a role in the maintenance of a healthy pregnancy and thus function in either contributing to or protecting from preterm birth. The application of next-generation sequencing (NGS) demonstrated a greater degree of microbial diversity both within and between women than previously recognized. The composition of the vaginal microbiome largely differs by age and ethnicity. This study aimed to examine differences in the microbial richness, diversity, and differential abundance of specific taxa throughout normal pregnancy and in preterm birth in Saudi Arabia women. Materials and Methods: We obtained vaginal swab samples from 29 Saudi women who were classified as either term (38-42 weeks, n = 17) or preterm (≤36 weeks, n = 12) in exclusion of any other medical or obstetric conditions. The vaginal microbiomes of these women were characterized by 16S ribosomal RNA (rRNA) gene sequencing of the V3-V4 region on the Illumina MiSeq. Results: As expected, the vaginal microbiomes of women with healthy ongoing pregnancies had lower richness and diversity. In the studied group, the dominant specie was Lactobacillus iners, however, women who experience PTB had a higher abundance than women with term deliveries. Conclusion: Our analyses indicate normal pregnancy is characterized by a microbiome that has low diversity and high stability. Healthy vaginas are typically described as having an abundance of a member of the genus Lactobacillus. In the present study, we provide further evidence that vaginal microbiome composition differs by ethnicity. Key words: Lactobacillus, preterm birth, vaginal microbiome, Dysbiosis. 
Supervisor : Prof. Dr. Rashad Rizq Al-Hindi 
Thesis Type : Doctorate Thesis 
Publishing Year : 1444 AH
2022 AD 
Co-Supervisor : Dr. Sherif Edris Ahmed 
Added Date : Monday, February 27, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سمر مقبل الحبرديAlhabardi, Samar MegbalResearcherDoctorate 

Files

File NameTypeDescription
 49033.pdf pdf 

Back To Researches Page