Document Details

Document Type : Thesis 
Document Title :
Assessing The Expression of The Immune-Related NLR Pyrin Domain Containing 2 (NLRP2) Gene Among Saudi Autistic Children
تقييم التعبير عن الجين المرتبط بالمناعة NLR المحتوي على البايرين ٢) (NLRP2 بين الأطفال السعوديين المصابين بالتوحد
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Autism spectrum disorder (ASD) is a complex neurodevelopmental disease described as a heterogeneous disorder characterized by symptoms, including language deficiencies and communication impairments. According to the recent findings, immune dysregulation could be a viable risk factor for neurodevelopmental abnormalities in people with ASD. Several genes are involved in the development of ASD. The NLRP2 is a member of the Nucleotide-binding oligomerization domain, Leucine-rich Repeat, and Pyrin domain-containing (NLRP) family. In addition, a study suggests the defect in regulating gene expression of inflammatory NLRP2 may take a place through embryo brain development of bipolar disorder patients. Therefore, the correlation between NLRP2 expression and ASD is still unknown. Consequently, this study aims to measure the expression of NLRP2 in 20 Saudi autistic children compared to 5 healthy children. The expression level of the NLRP2 was measured using the qRT-PCR. Results indicated a dysregulation of NLRP2 between autistic and control samples. There is a significant NLRP2 upregulation in 65% of ASD samples (Fold change = 6.503 ± 1.390) compared to the healthy children (p value= 0.0009). In addition, a significant NLRP2 downregulation in 35% of ASD samples (Fold change = -4.392 ± 0.968) when compared to healthy children (p value= 0.0069). Therefore, this study suggests a dysregulation of NLRP2 expression among ASD children compared to healthy children approving the influence of host immunity in ASD. Keywords: (ASD, NLRP2, immune dysregulation, qRT-PCR) 
Supervisor : Dr. Fatemah Basingab 
Thesis Type : Master Thesis 
Publishing Year : 1444 AH
2022 AD 
Added Date : Sunday, February 19, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أسماء عبدالله الغامديAlghamdi, Asmaa AbdullahResearcherMaster 

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