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Document Type |
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Thesis |
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Document Title |
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Analysis of Anti-inflammatory Cytokines in Sickle Cell Anemia Saudi Patients تحليل السايتوكينات المضادة للالتهابات عند مرضى فقر الدم المنجلي في المرضى السعوديين |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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One of the most common serious inherited disorders affecting millions of people worldwide is sickle cell anemia (SCA). It is a hemolytic deficiency that is characterized by strangely formed(sickles) red blood cells (RBCs) that are expelled from circulation at expanded rates, leading to anemia. It is caused by a mutated hemoglobin inheritance, which has a single amino acid substitution compared to normal adult hemoglobin, with valine substituting glutamic acid at the sixth residue of the Hb tetramer is two B chains. For SCA patients, chronic inflammatory conditions are associated with high rates of inflammation markers, such as adhesion molecule and cytokines. Cytokines are a group of small proteins that are essential in cell signaling. Anti-inflammatory cytokines are a series of immunoregulatory molecules that control the response of proinflammatory and has gained recent attention as anti-inflammatory mediator in SCA patients, the most interesting anti-inflammatory cytokines are IL-10, IL-4, IL-27, and IL-37. The aim of the study is to measure the concentration of the anti- inflammatory cytokine in 3 groups, SCA patients without the use of any medication, SCA patients under hydroxy urea therapy and healthy people male and female in the general Saudi population using a total of 78 chosen subjects with a range of 20-45 years for each group. Using ELISA kits, cytokine levels were measured in the plasma patients. The results of the study indicated that anti-inflammatory cytokine elevated in SCA steady state and SCAHU patients compared to control individual (P= 0.001) and there is no significant different between SCA in steady state and SCAHU. These Anti-inflammatory cytokines including IL-27 and IL-37 which detected in this research for the first time in SCA patients in KSA have a role in keep patients in a steady-state and reducing inflammation, therefore more research, and studies to understanding the roles of different cytokines in the pathology of SCA is essential for the development of effective therapies for this disease. |
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Supervisor |
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Dr. Nuha Alkhattabi |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1443 AH
2022 AD |
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Co-Supervisor |
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Dr. Nesrin Tarbiah |
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Added Date |
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Tuesday, December 20, 2022 |
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Researchers
| ريما صالح العامري | Alamri, Reema Saleh | Researcher | Master | |
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