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Document Type |
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Thesis |
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Document Title |
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MODULATORY EFFECT OF PROPOLIS AGAINST NEPHROTOXICITY INDUCED IN RATS BY METHOTREXATE تعديل السمية الكلوية المستحثة في الجرذان بالميثوتركسيت باستخدام دنج العسل |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Propolis exhibits an antioxidant and anti-inflammatory actions may facilitate modulatory effect against methotrexate nephrotoxicity. The aim of this study is to evaluate the protective effect of propolis extract on nephrotoxicity induced by MTX in rats at the biochemical and histopathological levels. Thirty-six adult male Wister rats distributed into four groups (9 rats/group). Group I (control group) were served as normal control. Group II (MTX group) were injected with MTX 20 mg/Kg/day. Group III (propolis group) were administrated propolis 100 mg/kg/day. Group IV (MTX+ propolis group) were administrated the same doses of MTX and propolis. Renal functions, oxidative stress markers, and histopathological changes were evaluated. In the MTX group, the creatinine, urea, MDA, GPx, GST, cytochrome P450, and NOS levels were higher compared to the control group, while protein and GSH levels decreased. Compared to the MTX group, the urea, kidney MDA, GPx, CAT, GST and NOS levels decreased in addition to increased protein and GSH levels in the MTX+Propolis group. Propolis improved the renal tubules in addition glomeruli structures were better than the MTX-treated group. MTX induced the nephrotoxicity in rats by increasing oxidative stress. Propolis treatment reduced methotrexate nephrotoxicity in rats through its antioxidant property. The oxidative, antioxidant and detoxified biomarkers were ameliorated in rats induced nephrotoxicity by MTX and treated with propolis. |
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Supervisor |
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Dr. Jalaluddin Awliya Khan |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1441 AH
2020 AD |
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Added Date |
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Sunday, August 23, 2020 |
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Researchers
| تهاني مقحم النومسي | AlNomsi, Tahani Moqham | Researcher | Master | |
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