Document Details

Document Type : Thesis 
Document Title :
Drug Abuse -Related Biomarkers that Accelerate Neurodegenerative Disorders
المؤشرات الحيوية المتعلقة بالأمفيتامين التي تسرع من الاضطرابات العصبية التنكسية
 
Subject : Faculty of Applied Medical Sciences 
Document Language : Arabic 
Abstract : Introduction Amphetamine addiction has high prevalence worldwide though it causes dangerous physical and psychotic problems including neurodegeneration. Alzheimer's disease (AD) is considered to be one of the most common neurodegenerative disorder. Some specific inflammatory biomarkers are linked to AD. On the same line, previous studies found that those biomarkers were found in amphetamine addicts too. Thus, the present study aims to investigate the association between AD and amphetamine addiction. Method This is a case-control observational study. Seventeen amphetamine-drug addicts with age between 23- 40 were recruited from Al Amal Psychiatric hospital. Matched age and sex 19 healthy subjects were recruited, as well. After obtained ethical approval and informed consent, blood was drown to measure serum alpha 1 antichymotrypsin (ACT), pigment epithelium-derived factor (PEDF), and macrophage inflammatory protein-4 (MIP-4) using Luminex technique. Moreover, the correlation between liver function enzymes and predictive biomarkers of AD in amphetamine addicts was also investigated. Results Levels of serum ACT, PEDF, and MIP-4 showed a significant increase in amphetamine addicts compared to healthy control (p=0.03, p=0.001, and p=0.012; respectively). Pearson’s correlation test showed that the decreased level of ALT and the elevated AST to ALT ratio with PEDF biomarker in amphetamine addicts (r= -0.618, 0.651 and p=0.0001). Conclusion This study highlighted the importance of the interaction and the association between the changes of those inflammatory biomarkers and the development of AD in the amphetamine addicts. 
Supervisor : Dr. Aziza R. Al-Rafiah 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2020 AD 
Added Date : Wednesday, June 24, 2020 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
محمد موسى أبوعلهAbu-Illah, Mohammed MousaResearcherMaster 

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