Document Details

Document Type : Thesis 
Document Title :
Role of combined administration of Cu –Nicotinic acid and Coenzyme Q10 against aluminum chloride –induced oxidative stress in rat brain
دور مشاركة معقد – حمض نيكوتينات النحاس (1) والانزيم كيو(10) ضد الاجهاد التأكسدي الناجم عن كلوريد الألومنيوم في دماغ الجرذان
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Alzheimer's disease (AD) is the most common chronic neurodegenerative disorder associated with aging. This study aimed to explore the modulatory effects of Coenzyme Q10 (CoQ10) (10 mg mg/kg., b.w.) and [Cu (I) – (nicotinic acid ) 2 ] 1 Cl – complex (Cu –N complex) (400 µg/kg., b.w.) on aluminium chloride (AlCl3) -100 mg/kg b.w.) induced rat model of AD. Our results revealed that oral administration of AlCl3 for 42 days significantly elevated the levels of brain myeloperoxidase (MPO) activity and IL-1β levels, while Catalase and Na+ / K+ ATPase activity were markedly decreased. Plasma ferric reducing ability of plasma (ferric reducing/antioxidant power (FRAP) and superoxide dismutase (SOD) levels were noticeably decreased but Aspartate Transaminase (AST) concentrations were significantly increased, confirming that abnormal inflammatory response is associated with AD. Treatment by CoQ10 and Cu – N complex restored the above mentioned parameters to about normal levels comparable to those of AD, indicating that IL-1β and Na+ / K+ ATPase activity may be considered as new biomarkers for AD. Histopathological and comet assay examinations confirmed the neuroprotective effect of CoQ10 and Cu – N complex. The present data advocate the possible beneficial effect of CoQ10 and Cu – N complex protecting the cells against hepatocellular damage and as therapeutic modality for Alzheimer's disease via its anti-inflammatory/antioxidant mechanism. 
Supervisor : Prof. Safaa Yousef Qusti 
Thesis Type : Master Thesis 
Publishing Year : 1440 AH
2019 AD 
Co-Supervisor : Dr. Maha Baljoon 
Added Date : Monday, March 4, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ابتسام صالح الزهرانيAlZahrani, Ebtesam SalehResearcherMaster 

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