تفاصيل الوثيقة نوع الوثيقة : مقال في مجلة دورية  عنوان الوثيقة : Glutamine metabolism in skeletal muscle of glucocorticoid-treated rats Glutamine metabolism in skeletal muscle of glucocorticoid-treated rats   الموضوع : الكيمياء الحيوية  لغة الوثيقة : الانجليزية  المستخلص : 1. The effect of dexamethasone (30 micrograms day-1 100 g-1 body weight) on the regulation of glutamine metabolism was studied in skeletal muscles of rats after 9 days of treatment. 2. Dexamethasone resulted in negative nitrogen balance, and produced increases in the plasma concentrations of alanine (23.4%) and insulin (158%) but a decrease in the plasma concentration of glutamine (28.7%). 3. Dexamethasone treatment increased the rate of glutamine production in muscle, skin and adipose tissue preparations, with muscle production accounting for over 90% of total glutamine produced by the hindlimb. 4. Blood flow and arteriovenous concentration difference measurements across the hindlimb showed an increase in the net exchange rates of glutamine (25.3%) and alanine (90.5%) in dexamethasone-treated rats compared with corresponding controls. 5. Dexamethasone treatment produced significant decreases in the concentrations of skeletal muscle glutamine (51.8%) and 2-oxoglutarate (50.8%). The concentrations of alanine (16.2%), pyruvate (45.9%), ammonia (43.3%) and inosine 5'-phosphate (141.8%) were increased. 6. The maximal activity of glutamine synthetase was increased (21-34%), but there was no change in that of glutaminase, in muscles of dexamethasone-treated rats. 7. It is concluded that glucocorticoid administration enhances the rates of release of both glutamine and alanine from skeletal muscle of rats (both in vitro and in vivo). This may be due to changes in efflux and/or increased intracellular formation of glutamine and alanine  ردمد : 0143-5221  اسم الدورية : Clinical Science  المجلد : 79  العدد : 2  سنة النشر : 1411 هـ 1990 م  نوع المقالة : مقالة علمية  تاريخ الاضافة على الموقع : Monday, December 5, 2011  الباحثون اسم الباحث (عربي) اسم الباحث (انجليزي) نوع الباحث المرتبة العلمية البريد الالكتروني محمد العرضاوي Ardawi, Mohammed باحث رئيسي دكتوراه   ياسر جمال Jamal, Yasir باحث مشارك دكتوراه   الملفات اسم الملف النوع الوصف  31525.pdf pdf   الرجوع إلى صفحة الأبحاث