تفاصيل الوثيقة نوع الوثيقة : مقال في مجلة دورية  عنوان الوثيقة : Glucose and glutamine metabolism in the small intestine of septic rats Glucose and glutamine metabolism in the small intestine of septic rats   الموضوع : الكيمياء الحيوية  لغة الوثيقة : الانجليزية  المستخلص : The intestinal metabolism of glucose and glutamine was studied in rats made septic by cecal ligation and puncture technique. Sepsis resulted in negative nitrogen balance and produced increases in the concentrations of blood pyruvate, lactate, alanine, and glutamine, and decreases in those of 3-hydroxybutyrate and acetoacetate. Both plasma insulin and glucagon concentrations were increased by 2.2- and 3.2-fold in septic rats, respectively. Portal-drained visceral blood flow increased in septic rats, and was accompanied by a decrease in the rates of utilization of glutamine and production of lactate, glutamate, and ammonia compared with those rates in sham-operated animals. Enterocytes isolated from septic rats showed decreased rates of glucose and glutamine utilization compared with cells isolated from corresponding controls. The maximal activities of hexokinase, 6-phosphofructokinase, pyruvate kinase, and glutaminase were decreased in intestinal mucosal scrapings of septic rats. It is concluded that a moderate form of sepsis decreases the rates of glucose and glutamine utilization (both in vivo and in vitro) by the epithelial cells of the small intestine. This may be caused by changes in the maximal activities of key enzymes in the pathways of glucose and glutamine metabolism in these cells as a metabolic adaptation to spare glucose and glutamine for use by other tissues  ردمد : 0022-2143  اسم الدورية : The Journal of Laboratory and Clinical Medicine  المجلد : 115  العدد : 6  سنة النشر : 1410 هـ 1990 م  نوع المقالة : مقالة علمية  تاريخ الاضافة على الموقع : Thursday, November 24, 2011  الباحثون اسم الباحث (عربي) اسم الباحث (انجليزي) نوع الباحث المرتبة العلمية البريد الالكتروني محمد العرضاوي Ardawi, Mohammed باحث رئيسي دكتوراه   ياسر جمال Jamal, Yasir باحث مشارك دكتوراه   عبدالرحمن آشي Ashy, AbdulRahman باحث مشارك دكتوراه   الملفات اسم الملف النوع الوصف  31318.pdf pdf   الرجوع إلى صفحة الأبحاث