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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
3D Anatomy-Based Planning Optimization For HDR Brachytherapy of Cervix Cancer
3D Anatomy-Based Planning Optimization For HDR Brachytherapy of Cervix Cancer
 
الموضوع : العلاج بالاشعاع 
لغة الوثيقة : الانجليزية 
المستخلص : Aim: To evaluate the dosimetric superiority of inverse planning optimization and isodose line manually optimization (both 3D planning methods) versus conventional treatment plan (point A planning method), using various dosimetric indices in HDR brachytherapy planning for cervical carcinoma. Methods and materials: The data from 10 patients treated with HDR brachytherapy for cervical cancer using tandem and ovoids has been analyzed. Target and organ at risk volumes were defined using systematic guidelines. Dose distributions were created according to three different dose calculation protocols: point A, isodose line manually optimization, and inverse planning and dose–volume histograms from these plans were analyzed, and all plans were evaluated for V100%, V95%, the conformity index CI = V100%/VCTV, and the dose homogeneity index DHI = (V100% - V150%)/ V100% for target. For rectum D5cc, V50%, V70% and V100% of prescription dose were evaluated. For bladder D5cc, V50%, V80% and V100% of prescription dose were evaluated. Results: Both 3D planning methods showed significant better target coverage compared with point A calculation: average 85.65% isodose manually shaping vs. 48.43% point A calculation (p < 0.003) and 90.33% inverse planning vs. 48.43% point A calculation (p < 0.001) for V7Gy. Dose homogeneity was better for both 3D planning protocols: average 0.33% isodose manually shaping vs. 0.39% point A calculation (p < 0.008) and 0.31% inverse planning vs. 0.39% point A calculation (p < 0.031) for DHI. For organs at risk, point A calculation average was 4.29 Gy vs. 4.99 Gy isodose manually shaping (p < 0.037) and 4.29 Gy point A calculation vs. 5.14 Gy inverse planning (p < 0.013) for D5cc of rectum; and average 4.88 Gy point A calculation vs. 6.32 Gy isodose manually shaping (p < 0.019) and 4.88 Gy point A calculation vs. 5.78 Gy inverse planning (p < 0.019) for D5cc of bladder. Conclusion: The 3D planning methods improve dose conformity and homogeneity of target coverage while minimizing dose to critical structures by chosen the appropriate priorities and allows for easy comparison between patients 
ردمد : 0000-0000 
اسم الدورية : Saudi Journal of Obstetrics and Gynecology 
المجلد : 11 
العدد : 2 
سنة النشر : 1430 هـ
2009 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Friday, July 29, 2011 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
ياسر بهادرBahadur, Yasir باحث رئيسيدكتوراهyasirbahadur@hotmail.com

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