تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
علاج التوبيريميت لعلاج الصرع الطفولى
Topiramate For The Treatment of Infants with Early Myoclonic Encephalopathy.
 
لغة الوثيقة : الانجليزية 
المستخلص : Background: Early myoclonic encephalopathy (EME) is a rare epileptic syndrome characterized by neonatal onset of severe recurrent seizures of multiple types often resistant to antiepileptic drugs (AEDs). Topiramate (TPM) is a new AED, which has a wide spectrum of antiepileptic activities suggesting a potentially valuable therapeutic profile. There are limited clinical data available on TPM use in infants. Methods: Prospective, open label, add on trial of TPM in treating a series of infants with EME. TPM was started at 12.5 mg/day and was increased by doubling the dose every week until the minimum effective dose was reached (seizure free outcome) or up to a maximum of 10 mg/kg/day. Results: Four consecutive infants (2 males and 2 females) were included. In addition to daily seizures, they all had global hypotonia, developmental delay, and progressive microcephaly. The syndrome was cryptogenic in 3, and one had nonketotic hyperglycinemia. Initial EEGs showed generalized epileptic burst suppression pattern. Infants were tried on multiple AEDs (6-11, mean 7.5) with no success. TPM was added at age 5-12 months (mean 9) reaching a maximum dose of 5.5-10 mg/kg/day (mean 7.6). The infants were then followed for up to 19 months (mean 13.5). After introducing TPM, one infant became completely seizure free and 3 had significant (>50%) seizure reduction. EEGs in 3 infants showed marked improvement. One infant had weight loss that resulted in discontinuing the drug after 6 months. Follow-up renal ultrasound was normal in all infants. Conclusions: TPM is effective and safe in treating infants with intractable epilepsy secondary to EME. 
ردمد : 0749-8063 
اسم الدورية : Neurosciences Journal 
المجلد : 2 
العدد : 8 
سنة النشر : 2003 هـ
2003 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Saturday, March 13, 2010 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
محمد جانjan, Mohammed باحثدكتوراه 

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اسم الملفالنوعالوصف
 25918.doc doc 

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