Document Details
|
Document Type |
: |
Thesis |
|
Document Title |
: |
Synthesis and Characterization of Layered Double Hydroxides Supported Nickel Catalyst for Suzuki C-C Coupling Reactions تحضير و توصيف حفاز النيكل المدعم على طبقات الهيدروكسيد المزدوجة لتفاعلات سوزوكي للاقتران بين كربون - كربون |
|
Subject |
: |
Faculty of Science |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
Coupling reactions are essential tools for the synthesis of essential organic molecules in the chemical industry, the synthesis of complex bioactive compounds in the pharmaceutical and agricultural industries. Suzuki cross-coupling reaction is originally palladium-catalyzed reaction and has been modified and developed over the years to give reliable, effective results under mild protocols. The Suzuki cross-coupling reaction still limited in scope due to higher levels of a noble metals catalysts needed for the reaction, expensive organic solvents and the purification of products, as well as the separation, recovery, reuse of the catalysts and leaching metals to the product reaction that have been considered drawbacks in this type of essential reactions especially in pharmaceutical fields.
Glaser homo-coupling reaction produces the conjugated 1,3-diynes that are one of the most versatile building block materials, especially in the fields of natural products, pharmaceuticals , polymers and medicinal chemistry due to their ubiquitous structural motifs, they exhibit a range of biological activities such as anti-HIV, antifungal, anti-inflammatory, antibacterial, antivirus and anticancer activities.
Hence, this study was proceeded to prepare a new efficient catalyst for the Suzuki cross-coupling reaction and Glaser homo-coupling reaction. Layered double hydroxide containing nickel (NiLDH) is a unique material with various practical applications in catalysis, adsorption, pharmaceutics, photochemistry, and electrochemistry. NiLDH as a catalyst was used as individual as-synthesized or calcined or combined with other metal cations or other different materials like Y-zeolite as was studied in this thesis.
A simple generic and efficient protocol was used for the preparation of NiLDH catalyst, where the catalyst was irradiated with ultrasound during the co-precipitation process. The catalytic activity of pure NiLDH and NiLDH@YZ hybrid catalysts were studied using alternative sustainable and environmentally techniques like microwave irradiation and mechanochemical mixing, respectively, to save energy, reduce reaction times and temperature, simplify experimental conditions, and increase the effectiveness of catalysts. |
|
Supervisor |
: |
Prof. Mohamed Mokhtar M. Mostafa |
|
Thesis Type |
: |
Doctorate Thesis |
|
Publishing Year |
: |
1441 AH
2020 AD |
|
Co-Supervisor |
: |
Prof. Elham Shafik Aazam |
|
Added Date |
: |
Saturday, June 6, 2020 |
|
Researchers
| غاليه سعيد الزهراني | Alzhrani, Ghalia Saeed | Researcher | Doctorate | |
|
Back To Researches Page
|