Document Details
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Document Type |
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Thesis |
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Document Title |
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INVESTIGATION OF ADIPONECTIN AND LEPTIN AS PREDICTIVE MARKERS IN CORONARY HEART DISEASE التحقق من التغيرات في الأديبونيكتين واللبتين كمتنبئات لأمراض القلب التاجية |
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Subject |
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Faculty of Applied Medical Sciences |
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Document Language |
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Arabic |
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Abstract |
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Coronary heart disease (CHD) is one of the major health problems worldwide. Up to now, no sensitive predictive markers, for early detection and prevention of this disease, are well defined. Adipokines such as; adiponectin and leptin have been suggested to have several functions in relation to the cardiac vascular system. The aim of this study was to investigate the changes in adiponectin, high molecular weight (HMW) isoform of adiponectin and leptin serum levels in CHD patients and evaluate their potential usefulness as predictive biomarkers for CHD. In this study, 50 CHD patients were recruited and serum glucose, insulin and lipid profiles were measured on COBAS® 6000 Roche analyzer. Also, adiponectin, HMW and leptin were measured using ELISA. Our results showed significant correlations between leptin and total cholesterol (TC) and LDL levels (P=0.016, P=0.045 respectively). While adiponectin showed highly significant correlation with HDL (r=0.376, P=0.007) and inverse significant correlation with triglyceride (TG) levels (r=-0.327, P=0.021). On the other hand, HMW had significant correlations only with HDL (P=0.038). Furthermore, the results demonstrated a significant association of adiponectin and leptin with the modifiable CHD markers. As predicted, they showed opposite yet significant changes with BMI in their association with lean vs obese CHD patients (P=0.046, P=0.008, respectively). In other words, leptin showed to be higher in obese than lean patients and the vice versa for adiponectin. Highly significant correlation between leptin and BMI were clearly shown in the male patients (P=0.005). Moreover, diabetic patients had a lower concentration of adiponectin than nondiabetic patients (P=0.013) and hypertensive patients had higher leptin concentrations than nonhypertensive patients (P=0.025). Finally, this result illustrated a significant inverse correlation of both total and HMW adiponectin with the atherogenic Index (AI) (P=0.006 P=0.037, respectively). In conclusion, the results showed significant correlations of adiponectin and leptin with other known indicators and risk factors of CHD, as well as confirming the anti-atherogenic effect adiponectin. |
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Supervisor |
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Dr. Kalthoum Al-Saqqaf |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1439 AH
2018 AD |
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Added Date |
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Wednesday, February 21, 2018 |
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Researchers
| روضه محمد Fallatah | فلاته, Rawdah Mohammed | Researcher | Master | |
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