Document Details

Document Type : Article In Conference 
Document Title :
Effects of Somatostatin and Prostanoids (PGE2) on Jejunal Contractile Activity in Schistosomiasis Infected Mice
آثار سوماتوستاتين و بروستانويدز ( بجي2 ) على نشاط جيجنال القابض في فئران بلهارسيا المصابة
 
Subject : Effects of Somatostatin and Prostanoids (PGE2) on Jejunal Contractile Activity in Schistosomiasis Infected Mice 
Document Language : English 
Abstract : Background / Aims: Somatostatin SOM) has proven useful in the treatment of visceral pain and motor dysfunction. Prostaglandins E2 (pGE2) is known to modify intestinal motility, but the receptor mediating its actions have not been ful1y characterized. The aim in this study was to investigate the effect of somatostatin on schistosomiasis induce hyperactivity of intestinal motility and to determine the role of PGE2 in regulating intestinal motility through inflammation. Methods: Experiments were performed in Swiss mice 4- and 8-weeks following infection with S. mansion compared to untreated controls. Jejunal motility was assessed using a Trendelenburg preparation to study aboral directed motor complexes (MC) as described previously (Abdu et al., AJP. Am J Physiol Gastrointestinal Liver Physiol 2002; 282(4): G624-633). Histological evaluation was used to determine the physiological characteristics of inflammation. Data were expressed as mean±SEM (n=6-16) and were analyzed by paired or un-paired t tests as appropriate. Results: Wall thickness of 4-wk infected jejunum was similar 10 control. However, 8-wk post infection, the muscular is and the mucosa were thickened compared to control and 4-wk infected animals. Infection had no significant effect on MC amplitude and intervals at 4-wk compared to control (Table I and 2), whereas, in the 8-wk post infection there was a significant increase In MC and decrease of intervals compared to control. PGE2 (I IJM) caused a significant decrease in amplitude and intervals of control, 4-wk and 8-wk post-infection (table 1). SOM (300 nM) in control animals significanlly inhibited MC intervals but had no significant effect on MC amplitude (P>O.I), table 2. The effect of SOM on MC intervals was attenuated at 8-wk post infection (P < 0.03) compared 10 contro\. Conclusion: PGE2 and SOM play a potential role in modulating motor dysfunction during inflammation. 
Conference Name : The 21 sI Inlernalional Symposium on Neurogaslroenlerology and Molility - Jeju Island. Korea 
Duration : From : 23/07/1428 AH - To : 26/07/1428 AH
From : 2/10/2007 AD - To : 5/10/2007 AD 
Publishing Year : 1428 AH
2007 AD 
Number Of Pages : 2 
Article Type : Article 
Conference Place : Dept. of Internal Medicine, Yenisei University College of Medicine, Korea 
Organizing Body : Dept. of Internal Medicine, Yenisei University College of Medicine, Korea 
Added Date : Sunday, February 27, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
اسامة عبدالله ابو زنادةabu zenadh, osama abdullahResearcherDoctorate 

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