Document Details

Document Type : Article In Journal 
Document Title :
NEUROTOXICITY OF SEA ANEMONE GYROSTOMA HELIANTHUS FROM THE RED SEA
السمية العصبية لنعمان البحر جيروستوما هيليانثس
 
Document Language : Arabic 
Abstract : The scientific names of the collected sea anemone samples were confirmed as Entacmaea quadricolor (Rueppellx Leuckant, 1828) or Gyrostoma helianthus (Hemprich and Ehrenberg 1834). The collected samples were obtained from the Red Sea at the vicinity of Hurghada. The crude aqueous ethanolic extract of the collected sea anemone was freeze-dried to be used in the determination of the Dose Response Curve in mice after i.p. injection. The profile of this curve showed that the threshold was at 20 mg/ml and a plateau at 28 mg/ml. The estimated LDJQ values of the Sea Anemone crude extract were " 19.28, 24.7 and 27.3 pg/insect for M.domestica, C.pipens and S.littoralis respectively while it was 732.8 mg/kg for mice when i.p. injected. On the other hand, the tested crude extract at the dose level 1/8 LD50 when i.p. injected in 20 g mice showed potent inhibitory effect against AchE activity in both brain and blood of mice. Maximum inhibition was recorded 30 min after treatment. Throughout the test period the enzyme activity showed tendency to restore its original value. No activity was detected against the tested bacterial and fungal species as well as against brine shrimp. 
ISSN : 3456 
Journal Name : Journal of Egyptian society for Toxicity 
Volume : 22 
Issue Number : 1 
Publishing Year : 1420 AH
2000 AD 
Article Type : Article 
Added Date : Saturday, January 8, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
محمد نصر الدين محمد جمعةGomaa, Mohamed Nasr Eldin mohamedInvestigatorDoctoratemngomaa@gmail.com

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