Document Details

Document Type : Article In Journal 
Document Title :
Stereoselective Synthesis and Antiviral Activity of (1E,2Z,3E)-1-(Piperidin-1-yl)-1-(arylhydrazono)-2-[(benzoyl/benzothiazol- 2-oyl)hydrazono]-4-(aryl1)but-3-enes.
تشييد مركبات الداى هيدرازون و اثبات التركيب الفراغى لها كمضادات للفيروسات
 
Subject : Organic Chemistry 
Document Language : English 
Abstract : The reaction of benzoyl hydrazine1aor benzothiazole-2-carbohydrazide1bwith 2-oxo-N-arylpropanehydrazonoyl chlorides 2a-dyielded (1Z,2E)-2-[(benzoyl/benzothiazol-2-oyl)hydrazono]-N-(aryl)propanehydrazonoyl chlorides3a-e. The reaction of3a-c with sodium benzenesulphinate furnished sulfones5a-c while the reaction of5d,e with hydroxyl amine afforded hydroxomoyl derivs.6a, b. The one-pot sterioselective reaction ofN-(aryl)propanehydrazonoyl chlorides3 with certain arom. aldehydes in the presence of piperidine resulted in the formation of (1E,2Z,3E)-1-(piperidin-1-yl)-1-(arylhydrazono)-2-[(benzoyl/benzothiazol-2-oyl)hydrazono]-4-(aryl1)-but-3-enes7a-g. X-ray anal. of piperidinyl amidrazone 7gshowed a conversion of its geometrical structure with respect to that of compd.3 and confirmed the stereoselectivity of the latter reaction. The piperidinyl amidrazones7a-g possessed a significant antiviral activity against herpes simplex viruses (HSV-1). Compd. 7d reduced the no. of viral plaques of herpes simplex type-1 (HSV-1) by 67%, with respect to the effect of ref. drug Aphidicolin. 
ISSN : 1319-0989 
Journal Name : Arts and Humanities Journal 
Volume : 343 
Issue Number : 3 
Publishing Year : 1431 AH
2010 AD 
Article Type : Article 
Added Date : Saturday, December 25, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
بكر فتحى عبد الوهابAbdel-Wahab, Bakr FathiResearcherDoctorate 

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