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Document Type |
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Article In Journal |
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Document Title |
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Synthesis of new 2-naphthyl ethers and their protective activities against DNA damage induced by bleomycin-iron. تشييد مركبات 2-نفثييل اثير جديدة كمضادات لتكسير الحامض النووى فى الخلايا السرطانية باستخدام البلوميسيين |
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Subject |
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Organic Chemistry |
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Document Language |
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English |
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Abstract |
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The reaction of 2-naphthyloxyacetic acid with thiosemicarbazide in the presence of phosphoryl chloride, followed by treatment with phenacyl bromides, led to the formation of imidazo[2,1-b][1,3,4]thiadiazoles. 2-(3-Naphthyloxy)acetohydrazide (I) on treatment with Et 2-(2-arylhydrazono)-3-oxobutanoates, 2-(methoxymethylene)malononitrile, or Et 2-cyano-3,3-bis(methylthio)acrylate led to the formation of substituted pyrazoles. The reaction of the hydrazide I with hydrazonoyl chlorides and 1,2,4,5-benzenetetracarboxylic-1,2:4,5-dianhydride produced bis-diazo compds. and a diimide, resp. All new compds. were tested for their protective activity against DNA damage induced by bleomycin-iron complex. 5-[(2-Naphthyloxy)methyl]-1,3,4-thiadiazol-2-amine showed the greatest protection against DNA damage, thus diminishing chromogen formation between the damaged DNA and thiobarbituric acid. |
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ISSN |
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0009-2363 |
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Journal Name |
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Chemical & Pharmaceutical Bulletin |
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Volume |
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57 |
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Issue Number |
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12 |
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Publishing Year |
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1430 AH
2009 AD |
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Article Type |
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Article |
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Added Date |
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Saturday, December 25, 2010 |
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Researchers
| بكر فتحى عبد الوهاب | Abdel-Wahab, Bakr Fathi | Researcher | Doctorate | |
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