Faculty of Science and Arts - Khulais | Researches | Synthesis, antiarrhythmic and anticoagulant activities of novel thiazolo derivatives from methyl 2-(thiazol-2-ylcarbamoyl)acetate.

Faculty of Science and Arts - Khulais

Document Details

Document Type	:	Article In Journal
Document Title	:	Synthesis, antiarrhythmic and anticoagulant activities of novel thiazolo derivatives from methyl 2-(thiazol-2-ylcarbamoyl)acetate. تصنيع مركبات الثيازول الجديدة المستخدمة كمضادات لتجلط الدم
Subject	:	Organic Chemistry
Document Language	:	English
Abstract	:	A series of novel thiazole derivs. were synthesized by initial condensation of Me 2-(thiazol-2-ylcarbamoyl)acetate with Ph isothiocyanate and further reactions using different org. reagents. The structures of newly synthesized compds. were confirmed by IR, 1H NMR, EIMS spectral data, and elemental anal. Initially the acute toxicity of the compds. was assayed via the detn. of their LD50. All the compds. were screened for their antiarrhythmic and anticoagulant activities and they showed high antiarrhythmic activity compared with procaine amide and lidocaine as pos. controls. The detailed synthesis, spectroscopic data, LD50, and pharmacol. activities of the synthesized compds. were reported.
ISSN	:	0223-5234
Journal Name	:	European Journal of Medicinal Chemistry
Volume	:	44
Issue Number	:	2
Publishing Year	:	1430 AH 2009 AD
Article Type	:	Article
Added Date	:	Saturday, December 25, 2010

Researchers

Researcher Name (Arabic)	Researcher Name (English)	Researcher Type	Dr Grade	Email
بكر فتحى عبد الوهاب	Abdel-Wahab, Bakr Fathi	Researcher	Doctorate

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