Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Synthesis and anti-arrhythmic activity of some piperidine-based 1,3-thiazole, 1,3,4-thiadiazole, and 1,3-thiazolo[2,3-c]-1,2,4-triazole derivatives. تحضير مركبات الثيازول و الثياديازول المحتوية على نواه البيبريدين و الأهمية البيولوجية لعلاج ضغط الدم |
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Subject |
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Organic Chemistry |
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Document Language |
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English |
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Abstract |
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Cyclization of 1-[4-(piperidin-1-yl)benzylidene]thiosemicarbazide with hydrazonoyl chlorides afforded 1,3-thiazole derivs., which underwent intramol. cyclization to give 1,3-thiazolo[2,3-c]-1,2,4-triazole derivs. Cyclization of 2-cyano-3-[4-(piperidin-1-yl)phenyl]prop-2-enethioamide with hydrazonoyl chlorides yielded 1,3-thiazoles. On the other hand, treatment of 3-oxo-3-(piperidin-1-yl)propanenitrile with Ph isothiocyanate in the presence of KOH resulted 3-anilino-3-mercapto-2-[(piperidin-1-yl)carbonyl]acrylonitrile; which underwent cyclization with hydrazonoyl chlorides to yield the corresponding 1,3,4-thiadiazole derivs., e.g, I. All the synthesized compds. were screened for their anti-arrhythmic activity. Some of them showed promised anti-arrhythmic activity. |
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ISSN |
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0026-9247 |
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Journal Name |
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Monatshefte fuer Chemie |
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Volume |
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140 |
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Issue Number |
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4 |
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Publishing Year |
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1430 AH
2009 AD |
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Article Type |
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Article |
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Added Date |
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Saturday, December 25, 2010 |
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Researchers
| بكر فتحى عبد الوهاب | Abdel-Wahab, Bakr Fathi | Researcher | Doctorate | |
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