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Document Type |
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Article In Journal |
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Document Title |
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Convenient synthesis and antimicrobial activity of new 3-substituted 5-(benzofuran-2-yl)-pyrazole derivatives. تحضير مركبات جديدة من البنزوفيرانيل بيرازول و الأهميه البيولوجية لهذه المركبات كمضادات للميكروبات |
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Subject |
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Organic Chemistry |
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Document Language |
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English |
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Abstract |
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The reaction of Et 4-(benzofuran-2-yl)-2,4-dioxobutanoate (I) with two moles of hydrazine hydrate afforded 5-(benzofuran-2-yl)-1H-pyrazole-3-carbohydrazide (II, R1 = H), while its reaction with equimolar amt. of phenylhydrazine gave an Et ester which then converted to 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (II, R1 = Ph). Various new compds. such as imides, acyl hydrazones, bi-pyrazoles, and 1,3-thiazole derivs. were prepd. from carbohydrazide derivs. II. The new compds. are tested for their antimicrobial activity. Compds. I, III (R1 = H) and IV (R1 = H, R2 = 2,4-di-ClC6H4; R1 = Ph, R2 = 4-NO2C6H4) showed antifungal activities against C. albicans. Also, compds. I, III (R1 = Ph), IV (R1 = Ph, R2 = 4-NO2C6H4), and V showed antibacterial activities. |
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ISSN |
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0365-6233 |
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Journal Name |
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Archiv der Pharmazie (Weinheim, Germany) |
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Volume |
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341 |
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Issue Number |
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11 |
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Publishing Year |
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1429 AH
2008 AD |
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Article Type |
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Article |
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Added Date |
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Saturday, December 25, 2010 |
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Researchers
| بكر فتحى عبد الوهاب | Abdel-Wahab, Bakr Fathi | Researcher | Doctorate | |
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