جامعة الملك عبدالعزيز

KING ABDULAZIZ UNIVERSITY

Center of Excellence In Genomic Medicine Research

Dr. Kalamegam Gauthaman

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Dr. Kalamegam Gauthaman

Assistant Professor
Coordinator of Tissue Culture Service Unit
Tissue Culture & Regenerative Medicine Research Group


Dr. Kalamegam Gauthaman, is as an Assistant Professor at the Centre of Excellence in Genomic Medicine Research, King Abdulaziz University since September 2012. He is a clinician scientist with more than 12 years of research experience. He had graduated with a medical degree (MBBS) from India in 1992 and later obtained his PhD in 2003 from the Department of Obstetrics and Gynaecology, National University of Singapore. His research interests are in the field of stem cells/Regenerative medicine and cancer cell biology.

His PhD and early post-doctoral work involved pharmacological management of male erectile dysfunction and the development of autologous corporal tissue using bio-engineering strategies for transplantation in non-human primates. He later moved into stem cell research and was involved in (i) evaluating the human embryonic stem cells (hESCs) as a pharmaceutical screening platform for the study of potential drugs; (ii) increasing their cell numbers in vitro using biodegradable nanoscaffolds and pharmacological agents, and (iii) identification of methods to overcome the inherent problem of tumorigenesis associated with hESCs. He was also working on the human Wharton's jelly stem cells (hWJSCs) and was involved in their (i) in vitro differentiation into useful tissues (viz. osteocytes, chondrocytes, neurons); (ii) optimizing the cryopreservation methods using pharmacological agents to improve thaw-survival efficiency; and (iii) evaluation of their anti-tumorigenic properties against various cancer cell lines both in vitro and in vivo.

His current research involves derivation of human bone marrow mesenchymal stem cells (BM-MSCs) from osteoarthritis patients under cGMP conditions, their characterization, expansion and differentiation into cartilage for autologus transplantation. To his credit he have three provisional patents (United States) and has published more than 35 original research articles in peer reviewed scientific journals. He has also contributed to five book chapters and several international conference presentations.

Funded Projects:
1. KACST grant titled, Human Wharton's Jelly stem cells (hWJSCs) and their putative role in ovarian cancer inhibition. Principal Investigator. 250 000.00 (USD). 2013.
2. KACST grant titled, Evaluation of human Wharton's jelly stem cells (hWJSCs) in the management of Alzheimer's disease. Principal Investigator. 500 000.00 (USD). 2013


Selected Publications:
1. Chondrocyte and mesenchymal stem cell-based therapies for cartilage repair in osteoarthritis and related orthopaedic conditions
Ali Mobasheri, Kalamegam Gauthaman, Giuseppe Musumecif, Mark E. Batt.
Maturitas 2014 78(3):188-98.

2. Common Cellular and Molecular Mechanisms Underlying Alzheimer’s Disease and Type 2 Diabetes: a Knowledge-Driven Approach.
Kalamegam Gauthaman, Peter Natesan Pushparaj, Manoharan Rajeshkumar, Kothandaraman Narashimman, Mohammed Al-Qahtani1, Nam Sang Cheung, Jayapal Manikandan
CNS & Neurological Disorders - Drug Targets. 2014. 13 (2): 247-258.

3. Human Wharton's jelly stem cell conditioned medium and cell-free lysate inhibit human osteosarcoma and mammary carcinoma cell growth in vitro and in xenograft mice
Gauthaman K, Fong CY, Arularasu S, Subramanian A, Biswas A, Choolani M, Bongso A.
J Cell Biochem. 114(2):366-77. doi: 10.1002/jcb.24367.

4. Human umbilical cord Wharton's jelly stem cell (hWJSC) extracts inhibit cancer cell growth in vitro.
Gauthaman K, Yee FC, Cheyyatraivendran S, Biswas A, Choolani M, Bongso A.
J Cell Biochem. 113(6):2027-39. doi: 10.1002/jcb.24073.

5. Extra-embryonic human Wharton's jelly stem cells do not induce tumorigenesis, unlike human embryonic stem cells.
Gauthaman K, Fong CY, Suganya CA, Subramanian A, Biswas A, Choolani M, Bongso A
Reprod Biomed Online. 24(2): 235-46. doi: 10.1016/j.rbmo.2011.10.007
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