Assistant of Pharmacogenomics & Drug Discovery Service Unit
Pharmacogenomics and Genomic Screening Groups
Dr. Rasool is well established and independent scientist in the field of medical biotechnology, molecular and cancer genetics. He did his PhD and post doctorate in the field of medical biotechnology and human molecular genetics with an interest in exploring human disease biology and mechanism of disease pathogenesis (especially of inherited and cancer genetics).
Dr. Rasool joined Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia, as Assistant Professor, from 24th January, 2012.
The short term objective of dr. Rasool's research is to identify gene variants contributing to human disorders. He also aims at understanding how gene variants mediate disease mechanisms using different biological model systems. The long term objective is to put his findings in contex and to clarify developmental processes, cellular differentiation and pathophysiological mechanisms related to specific traits.
Effects of gene variants are also analysed in different eukaryotic and prokaryotic cell systems as well as mouse models. Cell analysis using confocal- and electron microscopy, protein- and immunocharacterization are other mandatory tools.
1. The Role of Epigenetics in Personalized Medicine: Challenges and Opportunities
Rasool M, Malik A, Naseer MI, Manan A, Ansari SA, Begum I, Qazi MH, Pushparaj PN, Abuzenadah AM, Al-Qahtani MH, Kamal MA, Gan SH.
BMC Medical Genomics. 2015. doi: 10.1186/1755-8794-8-S1-S5.
2. Molecular characterization of Flt3 mutation in acute leukemia patients
Ishfaq M, Malik A, Faiz M, Sheikh I, Asif M, Khan MN, Qureshi MS, Zahid S, Manan A, Arooj M, Qazi MH, Chaudhary A, Alqahtani MH and Rasool M.
Asian Pacific Journal for Cancer Prevention. 2012; 13(9): 4581-4585.
3. Autosomal recessive pure hair and nail ectodermal dysplasia linked to chromosome 12p11.1-q14.3 without KRTHB5 gene mutation.
Rasool M, Nawaz S, Azhar A, Wajid M, Westermark P, Baig SM, Klar J, Dahl N
European journal of Dermatology. 2010; 20 (4):443-6.
4. A novel missense mutation in the EDA gene associated with X-linked recessive isolated hypodontia
Rasool M, Schuster J, Aslam M, Tariq M, Ahmad I, Ali A, Entesarian M, Dahl N, Baig SM
Journal of human genetics. 2008; 53: 894-898.
5. Abolished InsP3R2 function inhibits sweat secretion in both humans and mice. The Journal of Clinical Investigation
Klar J, Hisatsune C, Baig SM, Tariq M, Johansson ACV, Rasool M, Malik NA, Ameur A, Sugiura K, Feuk L, Mikoshiba K, Dahl N.
2014. 124 (11): 4773-4780. doi: 10.1172/JCI70720.