|Dr. Muhammad Imran Naseer
Assistant of High-Throughput Sequencing and Molecular Genetics Service Units
Genomic Screening & Neurogenomics Research Groups
Dr. Imran Naseer joined the CEGMR as a neuroscientist from Gyeongsang National University, South Korea. His area of expertise fall in molecular, cellular and developmental neuroscience. His PhD work was based on the effect of ethanol on siRNA-Mediated GABAB1 receptor expression for downstream signaling pathways, apoptotic neurodegeneration, maternal epileptic seizure and role of GABAB1 receptor expression in early development of pre and postnatal rat brain.
Currently he is involved in neurogenetic research program at CEGMR working on common neurologic disorders including Progressive Myoclonic, Juvenile Myoclonic,Idiopathic Generalized Epilepsy, microcephaly and other neurodegenerative and neurodevelopmental disorders in the Western region of Saudi Arabia using microarray platform for array CGH, CNV/SNP analysis and Next generation technology for expression and whole exome analysis. Dr. Imran has more than 10 years of research experience in Molecular biology techniques including real time RT PCR, molecular cloning, Western blot analysis, Cell biology, tissue culture, microscopy, flow cytometric analysis, Immunohistochemistry, Electron microscopy SEM, TEM, Confocal microscopy, animal models study, such as knock out, knock in mice model, primary, adult neuronal cell culturing and behavioral studies.
Further aim is to study the role of GABAB receptors and KIFs genes in early neurological defects related to neurodegenerative disorders in the Saudi Arabian Kingdom including Epilepsy, Alzheimer's and mental retardation. In addition, Dr. Imran uses Knock-in/Knock-out animal models based on the identification of novel mutations/findings related to epileptic patients for known as well as novel genetic aberrations to utilize them for testing novel therapeutic agents in a targeted therapeutic approach for epilepsy.
1. Application of advanced high-density array technology for mutational analysis to detect genome-wide copy number variations and single nucleotide polymorphisms in Juvenile Myoclonic Epilepsy from Western Saudi Arabia (KACST Strategic Grants 12-BIO3059-03).
2. Study of novel gene and mutations from primary Microcephaly in Saudi Arabia using advanced high-density array technology to detect genome-wide copy number variations and single nucleotide polymorphisms (KACST Large Grant APR 34-13).
3. Comprehensive molecular analysis of Kinesin superfamily proteins (KIFs) and their role in neurodegenerative disease model in Saudi Arabia (HiCi Grant KAU).
1. Osmotin Protects Against Ethanol-Induced Apoptotic Neurodegeneration in the Developing Rat Brain
Muhammad Imran Naseer, Meena L Narasimhan, Ikram Ullah, Hae Young Lee, Irina Sokolchik, Ray A. Bressan, Dae-Jin Yun, and Myeong Ok Kim.
(Cell death and disease 2014 Mar 27;5:e1150).
2. Apomorphine attenuate ethanol-induced neurodegeneration in adult rat cortex
Haroon Badshah, Ashfaq Ahmad, Tahir Ali, Muhammad Imran Naseer, Myeong Ok Kim
(Neurochemistry International 2014 Jul;74:8-15).
3. Thymoquinone and Vitamin C Attenuates Pentylenetetrazole-Induced Seizures via Activation of GABAB1 Receptor in Adult Rats Cortex and Hippocampus
Ikram Ullah, Muhammad Imran Naseer
(Neuromolecular Medicine 2015 In Press).
4. Genome wide analysis of novel copy number variations duplication/deletion of different epileptic patients in Saudi Arabia
Muhammad Imran Naseer, Muhammad Faheem, Maha Mohsin Al-Quaiti, Adeel G. Chaudhary, M.S. Jan, Mohammed H. Al-Qahtani
(BMC Genomics 2015, 16(Suppl 1):S10).